Taking paracetamol during pregnancy may reduce fertility of daughters https://t.co/UJl37oPs3w
2018 AAAS Annual Meeting February 15 - 19, 2018Austin, TX
Taking paracetamol during pregnancy may impair the future fertility of female offspring, according to a review published in Endocrine Connections. The article reviews three separate rodent studies that all report altered development in the reproductive systems of female offspring from mothers given paracetamol during pregnancy, which may impair their fertility in adulthood.
Paracetamol, or acetaminophen, is an over-the-counter treatment for pain relief that is commonly taken by pregnant women worldwide. Recent studies have linked paracetamol use during pregnancy with disruptions in the development of the male reproductive system but the effects on female offspring had not yet been investigated. In this article, Dr David Kristensen and colleagues from Copenhagen University Hospital, review the findings from three individual rodent studies that evaluated the effects of paracetamol taken during pregnancy on the development of the reproductive system in female offspring.
It is well known that exposure to some chemicals during pregnancy can cause developmental effects that may not manifest until much later in life. In rodents and humans, females are born with a finite number of eggs for reproduction in the future. In these reviewed studies, rodents given paracetamol during pregnancy, at doses equivalent to those that a pregnant woman may take for pain relief, produced female offspring with fewer eggs. This means that in adulthood, they have fewer eggs available for fertilisation, which may reduce their chances of successful reproduction, particularly as they get older.