Domestication of foxes shows changes in pituitary gland @joerogan https://t.co/DGRz89eMvV
CHAMPAIGN, Ill. -- A study of foxes offers new insights into the brain changes that occur in wild canids as they become more tame, researchers report. The study links fox domestication to changes in gene activity in the pituitary gland, a brain center that kicks out hormones to regulate various bodily functions, including the stress response.
The study, published in the journal G3: Genes | Genomes | Genetics, adds to a growing body of evidence suggesting that domestication alters animals' reactivity to stress.
"Other studies have seen a relationship between tameness and stress responses in animals," said Jessica Hekman, the first author of the paper who worked on the study as a graduate student in the laboratory of University of Illinois animal sciences professor Anna Kukekova. Hekman is now a postdoctoral researcher at the Broad Institute of MIT and Harvard. "In particular, the characteristic reduction in fearfulness of domesticated animals is closely linked to reductions in blood levels of ACTH, a hormone released by the anterior pituitary gland that, among other things, drives the stress response."
To get a better view of how this might occur, the researchers looked at gene activity in the anterior pituitary glands of foxes in a breeding program at the Institute of Cytology and Genetics in Novosibirsk, Russia, designed to study the evolutionary processes associated with domestication. They compared six foxes selectively bred for tameness and six foxes selectively bred for aggression.